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Factors affecting drug absorption from rectal suppositories, suppository bases, preparation of suppository, packing and storage. 1 Define suppositories and displacement value. 2 Discuss different suppository bases. 4 Give the ideal properties of suppository bases. 5 Discuss the problems encountered in manufacturing of suppositories such as hygroscopicity, incompatibilities, viscosity etc.

General introduction to the microbes and effect of temperature on the growth of Microorganisms. Principles and processes of sterilisation, sterilisation by filtration techniques and mechanisms involved in these techniques. What are the different methods of sterilization? Discuss in detail about two suitable examples. Mention suitable methods for the sterilization of thermolabile drugs and antibiotics. What is sterilization by filtration? Is therefore an absolute one.

Types- General requirements, Various components, container, closure, production facilities, procedures and equipment employed in the manufacture of parenterals. Freeze drying of parenteral formulations, quality control and packaging of parenterals. Study of official preparations like, water of injection, Calcium gluconate injection. Ansel Pharmaceutical Dosage Forms and Drug Delivery Systems.